Poster - Somatic variant detection from circulating tumor cells using targeted next-generation sequencing

Introduction

Somatic variant detection in oncology research provides insight into drug response and helps identify new therapeutic targets. A key limitation to this process is the availability of tumor tissue that adequately represents the current disease status. Development of a robust method for detecting mutational status from a blood sample would enable monitoring of tumor changes over time, which is impractical using tissue biopsies. A workflow is presented for analyzing somatic variants in circulating tumor cell (CTC) samples using next-generation sequencing (NGS).

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