In vitro and in vivo model systems to study microbial biofilm formation.
Laboratory of Pharmaceutical Microbiology, Ghent University, Gent, Belgium. Tom.Coenye@UGent.be
Biofilm formation is often considered the underlying reason why treatment with an antimicrobial agent fails and as an estimated 65-80% of all human infections is thought to be biofilm-related, this presents a serious challenge. Biofilm model systems are essential to gain a better understanding of the mechanisms involved in biofilm formation and resistance. In this review a comprehensive overview of various in vitro and in vivo systems is presented, and their advantages and disadvantages are discussed.
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