Antimicrob Agents Chemother. 2013 Nov 18. [Epub ahead of print]
Activity of Imipenem against Klebsiella pneumoniae Biofilms In Vitro and In Vivo.
Microbiology Branch, US Army Dental and Trauma Research Detachment, Institute of Surgical Research, Fort Sam Houston, TX 78234.
The encapsulated Klebsiella pneumoniae has emerged as one of the most clinically relevant and more frequently encountered opportunistic pathogens in combat wounds as the result of nosocomial infection. In this report, we show that Imipenem displayed potent activity against established K. pneumoniae biofilms under both static and flow conditions in vitro. Using a rabbit ear model, we also demonstrated that Imipenem was highly effective against preformed K. pneumoniae biofilms in wounds.
Keywords: Microbiology, Infectious Diseases, Biofilm