Nucleic acid modulators of glycoprotein VI

Publication number US8318923 B2
Publication type Grant
Application number US 12/793,572
Publication date Nov 27, 2012
Filing date Jun 3, 2010
Priority date Jun 3, 2009
Also published as CA2764449A1, 4 More »
Inventors Juliana M. Layzer, Christopher P. Rusconi, Douglas Brooks, Steven L. Zelenkofske
Original Assignee Regado Biosciences, Inc.
The present invention relates, in general, to a pharmacologic system to modulate the biology of platelets based upon a nucleic acid ligand that can interact with and modulate the activity of platelet glycoprotein GPVI to regulate platelet function. These nucleic acid ligands are also actively reversible using a modulator that inhibits the activity of the nucleic acid ligand to neutralize this pharmacologic effect and thereby restore GPVI function, including collagen binding, platelet adhesion, collagen-induced platelet activation, and collagen-induced platelet aggregation. The invention further relates to compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, as well as methods of using these agents and compositions in medical therapeutic and diagnostic procedures.