Nucleic acid modulators of glycoprotein VI

Publication number US8318923 B2
Publication type Grant
Application number US 12/793,572
Publication date Nov 27, 2012
Filing date Jun 3, 2010
Priority date Jun 3, 2009
Also published as CA2764449A1, 4 More »
Inventors Juliana M. Layzer, Christopher P. Rusconi, Douglas Brooks, Steven L. Zelenkofske
Original Assignee Regado Biosciences, Inc.
 
 
Abstract
 
The present invention relates, in general, to a pharmacologic system to modulate the biology of platelets based upon a nucleic acid ligand that can interact with and modulate the activity of platelet glycoprotein GPVI to regulate platelet function. These nucleic acid ligands are also actively reversible using a modulator that inhibits the activity of the nucleic acid ligand to neutralize this pharmacologic effect and thereby restore GPVI function, including collagen binding, platelet adhesion, collagen-induced platelet activation, and collagen-induced platelet aggregation. The invention further relates to compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, as well as methods of using these agents and compositions in medical therapeutic and diagnostic procedures.

 

Article

Have more questions? Submit a request

Comments

Powered by Zendesk