CELL MIGRATION probing cell movement with smarter tool

John Comley



Cell migration comprises the movement of cells from one location to another
in response to events, biological signals or environmental cues. Cell migration
plays a critical role in numerous normal biological processes and also in many
diseases. Most recent commercial activity around cell migration has been
directed towards developing tools that facilitate easy access/setup and add
greater reproducibility to assays. Researchers wanting to investigate cell
migration are now increasingly spoilt for choice. This is reflected not only in
the variety of cell culture inserts, stoppers, specialised microplates, microfluidic
devices and live cell compatible trackers that are now available to support cell
migration, but also by the efforts of instrument manufacturers to make
detection, reading, imaging and analysis of fluorescent and unlabelled cells easier
in both end point and kinetic motility assays. Many new and innovative assays
tools, some of which are reported in this article, not only facilitate the wider
investigation of cell migration assays but also contribute to a better
understanding of the process by which cells migrate. The latter is expected to
play a pivotal role in the development of novel therapeutics strategies and to
improving the treatment of a wide range of diseases.